8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
Triazolam
CAS: 28911-01-5
Molecular Formula: C17H12Cl2N4
8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine - Names and Identifiers
| Name | Triazolam |
| Synonyms | U-33,030 Triazolam TRIAZOLAM Triazolam solution Triazolam CIV (200 mg) triazolam100ugpermlinmethanol triazolam--dea schedule iv item TRIAZOLAM BENZODIAZEPINE ANXIOL triazolam 100 ug per ml in methanol 8-CHLORO-6-(2-CHLOROPHENYL)-1-METHYL-4H-1,2,4-TRIAZOLO[4,3-A]1,4-BENZODIAZEPINE 8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine triazolam 100 ug per ml in methanol |
| CAS | 28911-01-5 |
| EINECS | 249-307-3 |
| InChI | InChI=1/C17H12Cl2N4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)19)13-8-11(18)6-7-15(13)23(10)16/h2-8H,9H2,1H3 |
8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine - Physico-chemical Properties
| Molecular Formula | C17H12Cl2N4 |
| Molar Mass | 343.21 |
| Density | 1.2835 (rough estimate) |
| Melting Point | 209-212°C |
| Boling Point | 499.51°C (rough estimate) |
| Flash Point | 11°C |
| Water Solubility | 30mg/L(ambient temperature) |
| Vapor Presure | 1.51E-11mmHg at 25°C |
| pKa | pKa 1.52(H2O) (Uncertain);6.5(H2O) (Uncertain) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.6300 (estimate) |
| Physical and Chemical Properties | White or off-white crystalline powder, odorless. |
| Use | Neuroleptics, for various types of insomnia, also for Nervousness, Anxiety, etc |
8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine - Risk and Safety
| Risk Codes | R11 - Highly Flammable R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R36/38 - Irritating to eyes and skin. R39/23/24/25 - |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S7 - Keep container tightly closed. |
| UN IDs | 3249 |
| WGK Germany | 2 |
| RTECS | XZ5472500 |
| HS Code | 2933910000 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 in mice, rats (mg/kg): >100, >5000 orally (Pharm. Weekblad.) |
8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine - Standard
Authoritative Data Verified Data
This product is 1-methyl-8-chloro-6-(2-chlorophenyl) -4H- [1,2, 4] triazole [4,3-a] [1,4] Benzodiazepine weeds, calculated as dry product, containing C17H12C12N4 should be 97.0% ~ 103.0%.
Last Update：2024-01-02 23:10:35
8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline powder; Odorless,
- This product is soluble in glacial acetic acid or chloroform, slightly soluble in methanol, slightly soluble in ethanol or acetone, and almost insoluble in water.
Last Update：2022-01-01 11:30:44
8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine - Differential diagnosis
Authoritative Data Verified Data
- take this product, add anhydrous ethanol to dissolve and dilute to make a solution containing 5ug per lml, and measure by UV-Vis spectrophotometry (General rule 0401), there is a maximum absorption at a wavelength of 221nm.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 586).
Last Update：2022-01-01 11:30:44
8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine - Exam
Authoritative Data Verified Data
Related substances
take this product, add methanol to dissolve and make a solution containing about 0.5mg per 1 ml, as a test solution; Take appropriate amount of precision, A solution containing about 5ug per 1 ml was prepared as a control solution by quantitative dilution with methanol. According to the chromatographic conditions under the content determination item, respectively inject human liquid chromatograph into each lol of the control solution and the test solution, record the chromatogram to 3 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
loss on drying
take this product and dry under reduced pressure at 60°C for 16 hours, and the weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).
Last Update：2022-01-01 11:30:45
8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine - Content determination
Authoritative Data Verified Data
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Methanol-water (55:45) as mobile phase; The detection wavelength was 220nm. Take the appropriate amount of this product and Clonazepam, add methanol to dissolve and make a mixed solution containing 0.2mg in each lml, as a system applicable solution. Take 10ul injection liquid chromatograph, record chromatogram, triazolam peak and clonazepam peak separation degree should be greater than 9.0.
- determination method: take about 12mg of this product, weigh it accurately, put it in a 100ml measuring flask, add methanol to dissolve and dilute to the scale, shake it well, and use it as a test solution, take 10u1 injection liquid chromatograph, record chromatogram; Take triazolam reference substance, same method for determination. According to the external standard method to calculate the peak area, that is.
Last Update：2022-01-01 11:30:46
8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine - Category
Authoritative Data Verified Data
Anti-Anxiety drug.
Last Update：2022-01-01 11:30:46
8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:30:46
8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine - Triazolam tablets
Authoritative Data Verified Data
This product contains triazolam (C17H12C12N4) should be 90.0% to 110.0% of the label.
trait
This product is light blue.
identification
- take an appropriate amount of fine powder of this product (about 2mg of triazolam), add 10ml of chloroform, shake to dissolve, filter, evaporate the filtrate on a water bath, and add 1ml of dilute hydrochloric acid, the residue was dissolved, and an orange precipitate was generated by dropwise addition of a bismuth potassium iodide solution. After standing, the color became dark.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
examination
- Content uniformity take 1 tablet of this product, put it in a 10ml measuring flask (0.125mg specification) or a 20ml measuring flask (0.25mg specification), add an appropriate amount of 50% methanol solution, slightly warm, the triazolam was dissolved by shaking, allowed to cool, diluted to the scale with 50% methanol solution, shaken well, filtered, and then the filtrate was taken and determined according to the method under the content determination item; take another triazolam reference substance, precision weighing, add 50% methanol solution to dissolve and make a solution containing about 12.5ug per 1 ml, the same method for determination, calculation of content, should comply with the provisions (General 0941).
- the dissolution of this product, according to the dissolution and release determination method (General rule 0931 third method), water 200ml as the dissolution medium, the speed of 75 rpm, according to the law, after 30 minutes, 10ml of the solution was taken, filtered, and the filtrate was taken and determined according to the method under the content determination item. Another 10mg of triazolam reference substance was taken, precisely weighed and placed in a 100ml measuring flask, add 50% methanol solution to dissolve and dilute to the scale, shake, take appropriate amount of precision, quantitative dilution with water to make about 0.625ug(0.125mg specification) or 1.25ug(0.25mg specification) per lml the solution was determined by the same method, and the dissolution amount of each tablet was calculated. The limit is 75% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
take 50 tablets of this product, precision weighing, fine grinding, precision weighing an appropriate amount (about 3mg equivalent to triazolam), put it in a 25ml measuring flask, add 50% methanol solution 15ml, slightly warm, the triazolam was dissolved by shaking, allowed to cool, diluted to the scale with 50% methanol solution, shaken well, filtered, and the continued filtrate was taken as the test solution, precision weighing, plus 50% methanol dissolved and quantitative dilution to make a solution containing about 0.12mg per 1 ml, as a reference solution. According to the chromatographic conditions under the item of triazolam content determination, 10ul of each of the reference solution and the test solution is accurately measured, and the human liquid chromatograph is injected respectively to record the chromatogram. According to the external standard method to calculate the peak area, that is.
category
Same as triazolam.
specification
(1)0. 125mg (2)0. 25mg
storage
light shielding, sealed storage.
Last Update：2022-01-01 11:30:47
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